Record:
Last week: SU – 43-14; ATS – 22-29-3; O/U – 28-24-2
Overall: SU – 396-118; ATS – 203-201-8; O/U – 217-186-9
Upsets are bold underlined
(Results in parentheses; wins are underlined; losses in italics)
* – Picks with extreme confidence ATS
^ – Picks with low confidence ATS
| Thursday, Oct. 27 | |||
| Matchup | Time (ET) | TV Coverage | Prediction (Result) |
| #22 Virginia Tech (-4) at Pittsburgh (O/U 56.5) | 7 p.m. | ESPN | Virginia Tech, 34-27 (Virginia Tech, 39-36) |
| Akron (-17.5) at Buffalo (O/U 57) | 7:30 p.m. | ESPN3 | Akron, 31-17 (Buffalo, 41-20) |
| Appalachian State (-5.5) at Georgia Southern (O/U 44.5) | 7:30 p.m. | ESPNU | Appalachian State, 28-21 (Appalachian State, 31-10) |
| Ohio (+16) at Toledo (O/U 58.5) | 7:30 p.m. | CBSSN | Toledo, 38-21 (Ohio, 31-26) |
| California (+16) at USC (O/U 75.5) | 10:30 p.m. | ESPN | USC, 41-21 (USC, 45-24) |
| Friday, Oct. 28 | |||
| Matchup | Time (ET) | TV Coverage | Prediction (Result) |
| #25 Navy (+7) at USF (O/U 63) | 7 p.m. | ESPN2 | USF, 34-28 (USF, 52-45) |
| San Diego State (-6) at Utah State (O/U 43.5) | 8 p.m. | CBSSN | San Diego State, 31-20 (San Diego State, 40-13) |
| Air Force (-14) at Fresno State (O/U 53.5) | 10:30 p.m. | ESPN2 | Air Force, 24-17 (Air Force, 31-21) |
| Saturday, Oct. 29 | |||
| Matchup | Time (ET) | TV Coverage | Prediction (Result) |
| Duke (+6.5) at Georgia Tech (O/U 50.5) | Noon | RSN | Georgia Tech, 24-14 (Georgia Tech, 38-35) |
| Kansas State (-6.5) at Iowa State (O/U 50.5) | Noon | FSN | Kansas State, 27-17 (Kansas State, 31-26) |
| Kent State (+14.5) at Central Michigan (O/U 45.5) | Noon | CBSSN | Central Michigan, 34-14 (Kent State, 27-24) |
| Kentucky (+4.5) at Missouri (O/U 70.5) | Noon | SECN | Kentucky, 37-31 (Kentucky, 35-21) |
| #5 Louisville (-31.5) at Virginia (O/U 69) | Noon | ABC/ESPN2 | Louisville 41-14 (Louisville, 32-25) |
| #3 Michigan (-24) at Michigan State (O/U 54) | Noon | ESPN | Michigan, 42-14 (Michigan, 32-23) |
| Minnesota (-10) at Illinois (O/U 47) | Noon | BTN | Minnesota, 34-20 (Minnesota, 40-17) |
| #24 Penn State (-11.5) at Purdue (O/U 56.5) | Noon | ABC/ESPN2 | Penn State, 31-21 (Penn State, 62-24) |
| UCF (+9) at Houston (O/U 58.5) | Noon | ESPNU | Houston, 31-21 (Houston, 31-24) |
| Connecticut (+7) at East Carolina (O/U 54) | Noon | ESPNews | Connecticut, 24-21 (East Carolina, 41-3) |
| Wagner (NL) at Massachusetts | Noon | ASN | Massachusetts, 41-14 (Massachusetts, 34-10) |
| #9 West Virginia (-3.5) at #21 Oklahoma State (O/U 65.5) | Noon | FOX | West Virginia, 41-31 (Oklahoma State, 37-20) |
| Boston College (+15) at NC State (O/U 49.5) | 12:30 p.m. | ACCN | NC State, 27-14 (Boston College, 21-14) |
| Army (+6.5) at Wake Forest (O/U 41.5) | 3:30 p.m. | RSN | Wake Forest, 21-14 (Army, 21-13) |
| #13 Baylor (-3) at Texas (O/U 69) | 3:30 p.m. | ABC | Baylor, 38-31 (Texas, 35-34) |
| Cincinnati (+7) at Temple (O/U 53.5) | 3:30 p.m. | CBSSN | Temple, 34-20 (Temple, 34-13) |
| #15 Florida (-7.5) vs. Georgia (at Jacksonville) (O/U 43.5) | 3:30 p.m. | CBS | Florida, 27-17 (Florida, 24-10) |
| Maryland (+5) at Indiana (O/U 51.5) | 3:30 p.m. | ESPNU | Indiana, 34-31 (Indiana, 42-36) |
| Miami (Fla.) (-2.5) at Notre Dame (O/U 58.5) | 3:30 p.m. | NBC | Miami, 31-24 (Notre Dame, 30-27) |
| Miami (Ohio) (+7) at Eastern Michigan (O/U 49.5) | 3:30 p.m. | ASN | Eastern Michigan, 34-28 (Miami, 28-15) |
| Northwestern (+26.5) at #6 Ohio State (O/U 53) | 3:30 p.m. | ESPN | Ohio State, 38-20 (Ohio State, 24-20) |
| Samford (NL) at Mississippi State | 3:30 p.m. | SECN | Mississippi State, 45-14 (Mississippi State, 56-41) |
| Texas Tech (+8.5) at TCU (O/U 85) | 3:30 p.m. | ESPN2 | TCU, 41-38 (Texas Tech, 27-24) |
| #4 Washington (-10) at Utah (O/U 52) | 3:30 p.m. | FS1 | Washington, 41-28 (Washington, 31-24) |
| Western Kentucky (-21) at Florida Atlantic (O/U 64.5) | 3:30 p.m. | ASN | Western Kentucky, 38-14 (Western Kentucky, 52-3) |
| SMU (+2.5) at Tulane (O/U 51) | 4 p.m. | ESPNews | SMU, 27-24 (SMU, 35-31) |
| Arizona State (+8) at Oregon (O/U 78) | 5 p.m. | Pac-12N | Oregon, 38-35 (Oregon, 54-35) |
| Georgia State (+3.5) at South Alabama (O/U 47) | 5 p.m. | ESPN3 | South Alabama, 27-21 (South Alabama, 13-10) |
| #8 Boise State (-13.5) at Wyoming (O/U 62.5) | 7 p.m. | CBSSN | Boise State, 31-21 (Wyoming, 30-28) |
| Kansas (+40.5) at #11 Oklahoma (O.U 67) | 7 p.m. | FS1 | Oklahoma, 42-7 (Oklahoma, 56-3) |
| Marshall (+16) at Southern Miss (O/U 64.5) | 7 p.m. | ASN | Southern Miss, 41-27 (Southern Miss, 24-14) |
| Middle Tennessee (-17) at FIU (O/U 63) | 7 p.m. | ESPN3 | Middle Tennessee, 44-20 (Middle Tennessee, 42-35) |
| #10 Nebraska (+8.5) at #17 Wisconsin (O/U 43) | 7 p.m. | ESPN | Wisconsin, 27-24 (Wisconsin, 23-17) |
| North Texas (+3.5) at UTSA (O/U 54) | 7 p.m. | KMYS-CW 35 | North Texas, 35-28 (UTSA, 31-17) |
| Rice (+29) at Louisiana Tech (O/U 72) | 7 p.m. | CampusInsiders | Louisiana Tech 42-21 (Louisiana Tech, 61-16) |
| ULM (+20) at Arkansas State (O/U 55) | 7 p.m. | ESPN3 | Arkansas State, 34-17 (Arkansas State, 51-10) |
| #19 Auburn (-4.5) at Ole Miss (O/U 63.5) | 7:15 p.m. | SECN | Ole Miss, 31-28 (Auburn, 40-29) |
| #18 Tennessee (-13.5) at South Carolina (O/U 50.5) | 7:15 p.m. | ESPN2 | Tennessee 38-14 (South Carolina, 24-21) |
| New Mexico State (+43.5) at #16 Texas A&M (O/U 69.5) | 7:30 p.m. | ESPNU | Texas A&M, 51-7 (Texas A&M, 52-10) |
| #2 Clemson (-4.5) at #14 Florida State (O/U 60.5) | 8 p.m. | ABC | Clemson, 34-27 (Clemson, 34-31) |
| Old Dominion (-4) at UTEP (O/U 55.5) | 8 p.m. | CUSA.TV | Old Dominion, 27-20 (Old Dominion, 31-21) |
| Tulsa (+6.5) at Memphis (O/U 72) | 8 p.m. | ESPNews | Memphis, 38-35 (Tulsa, 59-30) |
| UNLV (-3) at San Jose State (O/U 57.5) | 10:30 p.m. | CBSSN | UNLV, 31-27 (San Jose State, 30-24) |
| #23 Washington State (-13) at Oregon State (O/U 56.5) | 10:45 p.m. | ESPN2 | Washington, 31-21 (Washington, 31-24) |
| Stanford (-5.5) at Arizona (O/U 50.5) | 11 p.m. | FS1 | Stanford, 20-17 (Stanford, 34-10) |
| New Mexico (+3) at Hawaii (O/U 66) | 11:59 p.m. | Oceanic PPV | Hawaii, 41-24 (New Mexico, 28-21) |
