Record:
This week: SU – 7-0; ATS – 4-3-0; O/U – 4-3-0
Overall: SU – 282-79; ATS – 139-147-5; O/U – 135-153-3
(Results in parentheses)
| Saturday, October 16 | |||
| Matchup | Time | TV | Prediction |
| #18 Texas A&M (-11) at Missouri (O/U 59.5) | Noon | SECN | Texas A&M, 37-23 |
| #12 Michigan State (-4.5) at Indiana (O/U 48.5) | Noon | FS1 | Michigan State, 28-21 |
| Nebraska (-4.5) at Minnesota (O/U 49) | Noon | ESPN2 | Nebraska, 26-20 |
| Rutgers (-2) at Northwestern (O/U 45) | Noon | BTN | Rutgers, 23-19 |
| Auburn (+4.5) at Arkansas (O/U 54) | Noon | CBS | Arkansas, 28-23 |
| #21 Florida (-12) at LSU (O.U 59.5) | Noon | ESPN | Florida, 31-21 |
| #14 Oklahoma State (+3.5) at #16 Texas (O/U 60.5) | Noon | FOX | Texas, 35-30 |
| UCF (+21.5) at #2 Cincinnati (O/U 56.5) | Noon | ABC | Cincinnati, 41-17 |
| Yale (NL) at UConn | Noon | CBSSN | UConn, 28-24 |
| Ohio (+7.5) at Buffalo (O/U 56) | Noon | ESPN+ | Buffalo, 37-23 |
| Tulsa (-8) at USF (O/U 55.5) | Noon | ESPNU | Tulsa, 37-23 |
| Duke (+10.5) at Virginia (O/U 69.5) | 12:30 p.m. | CSS | Virginia, 38-24 |
| Ball State (-1) at Eastern Michigan (O/U 55) | 2 p.m. | ESPN+ | Ball State, 26-21 |
| Akron (+20) at Miami (Ohio) (O/U 50.5) | 2:30 p.m. | ESPN+ | Miami, 35-17 |
| Troy (-7.5) at Texas State (O/U 48) | 3 p.m. | ESPN+ | Texas State, 27-13 |
| Miami (Fla.) (+7.5) at North Carolina (O/U 63) | 3:30 p.m. | ACCN | North Carolina, 35-27 |
| Pittsburgh (-5) at Virginia Tech (O/U 56) | 3:30 p.m. | ESPN2 | Pittsburgh, 31-27 |
| Arizona (+6) at Colorado (O/U 46.5) | 3:30 p.m. | P12N | Colorado, 24-20 |
| Purdue (+11.5) at #3 Iowa (O/U 43) | 3:30 p.m. | ABC | Iowa, 31-10 |
| Bowling Green (+9) at Northern Illinois (O/U 45) | 3:30 p.m. | ESPN+ | Northern Illinois, 33-20 |
| Toledo (-5) at Central Michigan (O/U 52.5) | 3:30 p.m. | CBSSN | Toledo, 28-21 |
| Kent State (+7) at Western Michigan (O/U 68) | 3:30 p.m. | ESPNU | Western Michigan, 35-30 |
| #9 Kentucky (+21.5) at #1 Georgia (O/U 44.5) | 3:30 p.m. | CBS | Georgia, 28-13 |
| #23 BYU (+5) at #22 Baylor (O/U 51.5) | 3:30 p.m. | ESPN | Baylor, 28-27 |
| Fresno State (-3.5) at Wyoming (O/U 53.5) | 3:30 p.m. | FS2 | Fresno State, 34-24 |
| UAB (-16) at Southern Miss (O/U 43.5) | 3:30 p.m. | STAD | UAB, 27-10 |
| Western Kentucky (-13) at Old Dominion (O/U 66.5) | 3:30 p.m. | STAD | Western Kentucky, 41-30 |
| Texas Tech (-18.5) at Kansas (O/U 68) | 4 p.m. | ESPN+ | Texas Tech, 40-17 |
| Vanderbilt (+18.5) at South Carolina (O/U 51) | 4 p.m. | SECN | South Carolina, 31-17 |
| Rice (+17) at UTSA (O/U 53) | 6 p.m. | ESPN+ | UTSA, 35-17 |
| Utah State (-7) at UNLV (O/U 62.5) | 7 p.m. | CBSSN | Utah State, 41-27 |
| #8 Alabama (-17) at Mississippi State (O/U 58) | 7 p.m. | ESPN | Alabama, 41-20 |
| Colorado State (-11.5) at New Mexico (O/U 45) | 7 p.m. | STAD | Colorado State, 30-14 |
| Liberty (-33) at Louisiana-Monroe (O/U 57.5) | 7 p.m. | ESPN+ | Liberty, 45-10 |
| #17 N.C. State (-3) at Boston College (O/U 51) | 7:30 p.m. | ACCN | N.C. State, 26-21 |
| Iowa State (-6.5) at Kansas State (O/U 50.5) | 7:30 p.m. | ESPN2 | Iowa State, 28-24 |
| TCU (+13.5) at #4 Oklahoma (O/U 64) | 7:30 p.m. | ABC | Oklahoma, 35-27 |
| Stanford (-1) at Washington State (O/U 52.5) | 7:30 p.m. | ESPNU | Stanford, 27-21 |
| Ole Miss (-2.5) at Tennessee (O/U 82) | 7:30 p.m. | SECN | Ole Miss, 41-35 |
| Army (+14) at Wisconsin (O/U 38.5) | 8 p.m. | BTN | Wisconsin, 23-13 |
| UCLA (+1.5) at Washington (O/U 55) | 8:30 p.m. | FOX | UCLA, 31-27 |
| Louisiana Tech (-6.5) at UTEP (O/U 56) | 8 p.m. | ESPN+ | UTEP, 31-27 |
| Air Force (+3.5) at Boise State (O/U 51.5) | 9 p.m. | FS1 | Air Force, 28-27 |
| #19 Arizona State (+1) at Utah (O/U 51) | 10 p.m. | ESPN | Arizona State, 31-27 |
| Hawaii (+14) at Nevada (O/U 61) | 10:30 p.m. | CBSSN | Nevada, 42-24 |
| Friday, October 15 | |||
| Matchup | Time | TV | Prediction |
| #20 Clemson (-13.5) at Syracuse (O/U 45) | 7 p.m. | ESPN | Clemson, 23-20 (Clemson, 17-14) |
| Marshall (-11) at North Texas (O/U 66) | 7 p.m. | CBSSN | Marshall, 37-24 (Marshall, 49-21) |
| San Diego State (-9.5) at San Jose State (O/U 41) | 10:30 p.m. | CBSSN | San Diego State, 31-20 (San Diego State, 19-13 OT) |
| California (-13.5) at #15 Oregon (O/U 54) | 10:30 p.m. | ESPN | Oregon, 31-17 (Oregon, 24-17) |
| Thursday, October 14 | |||
| Matchup | Time | TV | Prediction |
| Navy (+11) at Memphis (O/U 56) | 7:30 p.m. | ESPN | Memphis, 34-24 (Memphis, 35-17) |
| Georgia Southern (+3) at South Alabama (O/U 49.5) | 7:30 p.m. | ESPNU | South Alabama, 30-23 (South Alabama, 41-14) |
| Tuesday, October 12, 2021 | |||
| Matchup | Time | TV | Prediction |
| Appalachian State (-4.5) at Louisiana (O/U 57.5) | 7:30 p.m. | ESPN | Louisiana, 28-24 (Louisiana, 41-13) |
