Record:
Last week: SU – 1-0; ATS – 1-0-0; O/U – 1-0-0
Overall: SU – 276-79; ATS – 136-144-5; O/U – 132-150-3
(Results in parentheses)
| Thursday, October 14 | |||
| Matchup | Time | TV | Prediction |
| Navy (+11) at Memphis (O/U 56) | 7:30 p.m. | ESPN | Memphis, 34-24 |
| Georgia Southern (+3) at South Alabama (O/U 49.5) | 7:30 p.m. | ESPNU | South Alabama, 30-23 |
| Tuesday, October 12, 2021 | |||
| Matchup | Time | TV | Prediction |
| Appalachian State (-4.5) at Louisiana (O/U 57.5) | 7:30 p.m. | ESPN | Louisiana, 28-24 (Louisiana, 41-13) |
