Record:
Last week: SU – 15-5; ATS – 7-11-0; O/U – 9-8-1
Overall: SU – 15-5; ATS – 7-11-0; O/U – 9-8-1
(Results in parentheses; wins are underlined; losses in italics)
| Friday, September 10 | |||
| Matchup | Time (ET) | TV | Prediction |
| Kansas (+27) at Coastal Carolina (O/U 53) | 7:30 p.m. | ESPN2 | Coastal Carolina, 34-14 |
| N.C. A&T (NL) at Duke | 8 p.m. | ACCN | Duke, 41-17 |
| North Dakota (NL) at Utah State | 9 p.m. | CBSS | Utah State, 34-24 |
| UTEP (+27) at Boise State (O/U 55.5) | 9:30 p.m. | FS1 | Boise State, 38-20 |
| Saturday, September 11 | |||
| Matchup | Time (ET) | TV | Prediction |
| Illinois (+10) at Virginia (O/U 55) | 11 a.m. | ACCN | Virginia, 34-27 |
| VMI (NL) at Kent State | 11:30 a.m. | ESPN3 | Kent State, 31-24 |
| Western Kentucky (+6.5) at Army (O/U 54) | 11:30 a.m. | CBSS | Army, 28-21 |
| Kennesaw State (NL) at Georgia Tech | Noon | CSS | Georgia Tech, 34-10 |
| Norfolk State (NL) at Wake Forest | Noon | ACCN | Wake Forest 48-7 |
| Tulsa (+13.5) at Oklahoma State (O/U 52.5) | Noon | FS1 | Oklahoma State, 31-20 |
| Youngstown State (NL) at Michigan State | Noon | BTN | Michigan State, 41-10 |
| Miami (Ohio) (+19.5) at Minnesota (O/U 55.5) | Noon | ESPNU | Minnesota, 41-17 |
| Indiana State (NL) at Northwestern | Noon | BTN | Northwestern 38-3 |
| #15 Oregon (+14) at #4 Ohio State (O/U 63.5) | Noon | FOX | Ohio State, 34-23 |
| Pittsburgh (-3) at Tennessee (O/U 54.5) | Noon | ESPN | Pittsburgh, 24-21 |
| Alabama State (NL) at No. 17 Auburn | Noon | SECN | Auburn, 45-7 |
| South Carolina (+2) at East Carolina (O/U 55.5) | Noon | ESPN2 | South Carolina, 31-21 |
| #9 Florida(-29) at USF* (O/U 57.5) | 1 p.m. | ABC | Florida, 41-14 |
| Wyoming (-7) at Northern Illinois (O/U 45.5) | 1:30 p.m. | ESPN+ | Wyoming, 24-20 |
| Rutgers (-2) at Syracuse (O/U 51.5) | 2 p.m. | ACCN | Rutgers, 31-24 |
| Middle Tennessee (+19) at Virginia Tech (O/U 54) | 2 p.m. | ACCN | Virginia Tech, 42-17 |
| Duquesne (NL) at Ohio | 2 p.m. | ESPN3 | Ohio, 34-7 |
| Toledo (-16.5) at #7 Notre Dame (O/U 53.5) | 2:30 p.m. | Peacock | Notre Dame, 38-17 |
| Robert Morris (NL) at Central Michigan | 3 p.m. | ESPN3 | Central Michigan, 41-14 |
| Purdue (-33.5) at UConn (O/U 57.5) | 3 p.m. | CBSS | Purdue, 45-14 |
| #5 Texas A&M (-17) at Colorado (O/U 52) | 3:30 p.m. | FOX | Texas A&M, 34-21 |
| Buffalo (+13.5) at Nebraska (O/U 52.5) | 3:30 p.m. | BTN | Nebraska, 31-28 |
| Ball State (+22) at #13 Penn State (O/U 54) | 3:30 p.m. | FS1 | Penn State, 35-14 |
| Temple (-6.5) at Akron (O/U 52) | 3:30 p.m. | ESPN+ | Temple, 30-27 |
| UAB (+26) at #2 Georgia (O/U 44.5) | 3:30 p.m. | ESPN2 | Georgia, 31-10 |
| California (+10) at TCU (O/U 48) | 3:30 p.m. | ESPNU | TCU, 30-17 |
| Murray State (NL) at #6 Cincinnati | 3:30 p.m. | ESPN+ | Cincinnati, 45-7 |
| Air Force (-6.5) at Navy (O/U 43) | 3:30 p.m. | CBS | Air Force, 27-20 |
| Boston College (-37.5) at UMass (O/U 59) | 3:30 p.m. | FLOF | Boston College, 41-7 |
| Georgia Southern (+7) at FAU (O/U 49) | 3:30 p.m. | STAD | FAU, 27-21 |
| South Alabama (-15) at Bowling Green (O/U 51) | 4 p.m. | ESPN+ | South Alabama, 31-21 |
| Mercer (NL) at #1 Alabama | 4 p.m. | SECN | Alabama, 51-7 |
| #11 Iowa (+4.5) at #10 Iowa State (O/U 45) | 4:30 p.m. | ABC | Iowa, 23-20 |
| South Carolina State (NL) at #8 Clemson | 5 p.m. | ACCN | Clemson, 49-7 |
| LIU (NL) at West Virginia | 5 p.m. | ESPN+ | West Virginia, 45-10 |
| Illinois State (NL) at Western Michigan | 5 p.m. | ESPN3 | Western Michigan, 34-21 |
| Portland State (NL) at Washington State | 6 p.m. | P12N | Washington State, 38-17 |
| Lamar (NL) at UTSA | 6 p.m. | ESPN3 | UTSA, 41-14 |
| Gardner-Webb (NL) at Charlotte | 6 p.m. | ESPN3 | Charlotte, 31-17 |
| Houston (-8) at Rice (O/U 54.5) | 6:30 p.m. | CBSS | Houston, 28-21 |
| N.C. Central (NL) at Marshall | 6:30 p.m. | ESPN+ | Marshall, 45-14 |
| Bethune-Cookman (NL) at UCF | 6:30 p.m. | ESPN+ | UCF, 48-7 |
| Appalachian State (+8) at #25 Miami (Fla.) (O/U 54.5) | 7 p.m. | ESPNU | Miami, 31-28 |
| Southern Illinois (NL) at Kansas State | 7 p.m. | ESPN+ | Kansas State, 45-17 |
| Western Carolina (NL) at #3 Oklahoma | 7 p.m. | PPV | Oklahoma, 55-7 |
| Eastern Michigan (+25.5) at #16 Wisconsin (O/U 51.5) | 7 p.m. | FS1 | Wisconsin, 41-14 |
| Memphis (-5) at Arkansas State (O/U 65) | 7 p.m. | ESPN+ | Memphis, 30-27 |
| SE Louisiana (NL) at Louisiana Tech | 7 p.m. | ESPN3 | Louisiana Tech, 41-24 |
| Nicholls (NL) at Louisiana | 7 p.m. | ESPN3 | Louisiana, 44-17 |
| #12 Texas (-6.5) at Arkansas (O/U 57) | 7 p.m. | ESPN | Texas, 31-27 |
| N.C. State (-2.5) at Mississippi State (O/U 55) | 7 p.m. | ESPN2 | N.C. State, 34-30 |
| Texas Southern (NL) at Baylor | 7 p.m. | ESPN+ | Baylor, 51-3 |
| North Texas (+22) at SMU (O/U 72) | 7 p.m. | ESPN+ | SMU, 41-24 |
| Stephen F. Austin (NL) at Texas Tech | 7 p.m. | ESPN+ | Texas Tech, 41-17 |
| New Mexico State (+18.5) at New Mexico (O/U 53) | 7 p.m. | STAD | New Mexico, 34-17 |
| Eastern Kentucky (NL) at Louisville | 7 p.m. | ACCN | Louisville, 45-14 |
| Grambling State (NL) at Southern Miss | 7 p.m. | ESPN3 | Southern Miss, 38-10 |
| Morgan State (NL) at Tulane | 7 p.m. | ESPN+ | Tulane, 45-10 |
| Liberty (-5) at Troy (O/U 60.5) | 7 p.m. | ESPN+ | Liberty, 34-27 |
| Texas State (+1) at FIU (O/U 54.5) | 7 p.m. | ESPN+ | FIU, 33-28 |
| Hampton (NL) at Old Dominion | 7 p.m. | ESPN3 | Old Dominion, 38-14 |
| Howard (NL) at Maryland | 7:30 p.m. | BTN | Maryland, 56-10 |
| Georgia State (+25.5) at #20 North Carolina (O/U 61) | 7:30 p.m. | CSS | North Carolina, 38-21 |
| Idaho (NL) at Indiana | 7:30 p.m. | BTN | Indiana, 41-17 |
| Missouri (+5) at Kentucky (O/U 52.5) | 7:30 p.m. | SECN | Kentucky, 28-20 |
| Austin Peay (NL) at #22 Ole Miss | 7:30 p.m. | ESPN+ | Ole Miss, 48-14 |
| Jacksonville State (NL) at Florida State | 8 p.m. | ACCN | Florida State, 51-21 |
| Washington (+6) at Michigan (O/U 50.5) | 8 p.m. | ABC | Michigan, 37-20 |
| McNeese (NL) at #24 LSU | 8 p.m. | ESPN+ | LSU, 49-17 |
| San Diego State (+1) at Arizona (O/U 48) | 10 p.m. | P12N | San Diego State, 23-20 |
| Vanderbilt (+7) at Colorado State (O/U 49.5) | 10 p.m. | CBSS | Colorado State, 27-23 |
| Cal Poly (NL) at Fresno State | 10 p.m. | Local | Fresno State, 38-13 |
| #19 Utah (-7) at BYU (O/U 47.5) | 10:15 p.m. | ESPN | Utah, 28-23 |
| Idaho State (NL) at Nevada | 10:30 p.m. | STAD | Nevada, 38-13 |
| UNLV (+32.5) at Arizona State (O/U 55) | 10:30 p.m. | ESPN2 | Arizona State, 44-14 |
| Stanford (+17.5) at #14 USC (O/U 51.5) | 10:30 p.m. | FOX | USC, 31-23 |
| Hawaii (+11) at Oregon State (O/U 61.5) | 11 p.m. | FS1 | Oregon State, 34-24 |
