Record:
This week: SU – 57-9; ATS – 38-21-0; O/U – 42-20
Overall: SU – 538-161; ATS – 284-268-5; O/U – 326-288-10
(Results in parentheses)
| Saturday, November 20 | |||
| Matchup | Time | TV | Prediction |
| #14 Wake Forest (+3.5) at #23 Clemson (O/U 56.5) | Noon | ESPN | Clemson, 38-30 (Clemson, (48-27) |
| Wofford (NL) at North Carolina | Noon | CSS | North Carolina, 51-17 (North Carolina, 34-14) |
| Florida State (+3) at Boston College (O/U 55.5) | Noon | ACCN | Boston College, 28-24 (Florida State, 26-23) |
| Texas (+2.5) at West Virginia (O/U 56.5) | Noon | ESPN2 | West Virginia, 31-24 (West Virginia, 31-23) |
| Iowa State (+3) at #9 Oklahoma (O/U 59) | Noon | FOX | Oklahoma, 31-24 (Oklahoma, 28-21) |
| Purdue (=11.5) at Northwestern (O/U 47.5) | Noon | BTN | Purdue, 31-14 (Purdue, 32-14) |
| #11 Michigan State (+19.5) at #2 Ohio State (O/U 70.5) | Noon | ABC | Ohio State, 34-21 (Ohio State, 56-7) |
| Rutgers (+17.5) at Penn State (O/U 45) | Noon | BTN | Penn State, 31-13 (Penn State, 28-0) |
| Kent State (-13.5) at Akron (O/U 72.5) | Noon | ESPN+ | Kent State, 38-17 (Kent State, 38-0) |
| Charleston Southern (NL) at #1 Georgia | Noon | ESPN+ | Georgia, 48-0 (Georgia, 56-7) |
| New Mexico State (+35.5) at Kentucky (O/U 60.5) | Noon | SECN | Kentucky, 48-10 (Kentucky, 56-16) |
| Tennessee State (NL) at Mississippi State | Noon | ESPN+ | Mississippi State, 48-14 (Mississippi Stae, 55-10) |
| Prairie View A&M (NL) at #18 Texas A&M | Noon | ESPN+ | Texas A&M, 51-10 (Texas A&M, 52-3) |
| UMass (+37.5) at Army (O/U 56) | Noon | CBSSN | Army, 48-10 (Army, 33-17) |
| South Florida (+5.5) at Tulane (O/U 60) | Noon | ESPN+ | South Florida, 28-21 (Tulane, 45-14) |
| FAU (+10.5) at Western Kentucky (O/U 64.5) | Noon | STAD | Western Kentucky, 38-27 (Western Kentucky, 52-17) |
| Texas State (+24.5) at Coastal Carolina (O/U 60) | 1 p.m. | ESPN+ | Coastal Carolina, 31-17 (Coastal Carolina, 35-21) |
| Illinois (+12.5) at #24 Iowa (O/U 38.5) | 2 p.m. | FS1 | Iowa, 24-17 (Iowa, 33-23) |
| Arkansas State (+16.5) at Georgia State (O/U 65.5) | 2 p.m. | ESPN3 | Georgia State, 35-17 (Georgia State, 28-20) |
| Georgia Tech (+17) at #5 Notre Dame (O/U 59) | 2:30 p.m. | NBC | Notre Dame, 41-14 (Notre Dame, 55-0) |
| Washington (-6.5) at Colorado (O/U 43) | 3 p.m. | P12N | Washington, 27-17 (Colorado, 20-17) |
| #7 Michigan (-15.5) at Maryland (O/U 57.5) | 3:30 p.m. | BTN | MIchigan, 41-21 (Michigan, 59-18) |
| Virginia (+14.5) at #12 Pittsburgh (O/U 66) | 3:30 p.m. | ESPN2 | Pittsburgh, 37-27 (Pittsburgh, 48-38) |
| Minnesota (-7.5) at Indiana (O/U 43.5) | 3:30 p.m. | BTN | Minnesota, 34-17 (Minnesota, 35-14) |
| Nebraska (+10) at #17 Wisconsin (O/U 43.5) | 3:30 p.m. | ABC | Wisconsin, 27-14 (Wisconsin, 35-28) |
| #25 Arkansas (+20.5) at #3 Alabama (O/U 58.5) | 3:30 p.m. | CBS | Alabama, 34-24 (Alabama, 42-35) |
| SMU (+10) at #4 Cincinnati (O/U 65.5) | 3:30 p.m. | ESPN | Cincinnati, 41-28 (Cincinnati, 48-14) |
| East Carolina (-4) at Navy (O/U 46.5) | 3:30 p.m. | CBSSN | East Carolina, 31-17 (East Carolina, 38-35) |
| Old Dominion (+3) at Middle Tennessee (O/U 49.5) | 3:30 p.m. | ESPN+ | Middle Tennessee, 31-27 (Old Dominion, 24-17) |
| Appalachian State (-9.5) at Troy (O/U 51.5) | 3:30 p.m. | ESPN+ | Appalachian State, 38-17 (Appalachian State, 45-7) |
| UAB (+4) at #16 UTSA (O/U 53.5) | 3:30 p.m. | ESPN+ | UTSA, 34-24 (UTSA, 34-31) |
| Marshall (-14.5) at Charlotte (O/U 61.5) | 3:30 p.m. | STAD | Marshall, 38-17 (Marshall, 49-28) |
| Syracuse (+11.5) at N.C. State (O/U 49.5) | 4 p.m. | ACCN | N.C. State, 38-21 (N.C. State, 41-17) |
| Florida (-8.5) at Missouri (O/U 69) | 4 p.m. | SECN | Missouri, 38-35 (Missouri, 24-23 OT) |
| UCLA (-3.5) at USC (O/U 65.5) | 4 p.m. | FOX | UCLA, 34-24 (UCLA, 62-33) |
| Kansas (+21.5) at TCU (O/U 64.5) | 4 p.m. | ESPN+ | TCU, 34-17 (TCU, 31-28) |
| Rice (+9.5) at UTEP (O/U 47) | 4 p.m. | ESPN+ | UTEP, 24-17 (UTEP, 38-28) |
| Temple (+21.5) at Tulsa (O/U 50.5) | 4 p.m. | ESPN+ | Tulsa, 38-14 (Tulsa, 44-10) |
| #15 BYU (-20.5) at Georgia Southern (O/U 57) | 4 p.m. | ESPN+ | BYU, 38-17 (BYU, 34-17) |
| UConn (+30.5) at UCF (O/U 55.5) | 4 p.m. | ESPN+ | UCF, 48-14 (UCF, 49-17) |
| #19 Louisiana (+4.5) at Liberty (O/U 53) | 4 p.m. | ESPNU | Louisiana, 31-24 (Louisiana, 42-14) |
| #20 Baylor (+2.5) at #21 Kansas State (O/U 50) | 5:30 p.m. | FS1 | Kansas State, 27-24 (Baylor, 20-10) |
| California (-2.5) at Stanford (O/U 45) | 7 p.m. | P12N | California, 21-17 (California, 41-11) |
| Auburn (-7.5) at South Carolina (O/U 45.5) | 7 p.m. | ESPN | Auburn, 31-21 (South Carolina, 21-17) |
| North Texas (-10) at FIU (O/U 57.5) | 7 p.m. | ESPN3 | North Texas, 38-14 (North Texas, 49-7) |
| Virginia Tech (+7) at Miami (Fla.) (O/U 55.5) | 7:30 p.m. | ACCN | Miami, 34-28 (Miami, 38-26) |
| South Alabama (+27.5) at Tennessee (O/U 61.5) | 7:30 p.m. | ESPNU | Tennessee, 41-14 (Tennessee, 60-14) |
| Vanderbilt (+36.5) at #10 Ole Miss (O/U 64.5) | 7:30 p.m. | SECN | Ole Miss, 41-17 (Ole Miss, 31-17) |
| #6 Oregon (+3) at Utah (O/U 58.5) | 7:30 p.m. | ABC | Utah, 38-31 (Utah, 38-7) |
| Wyoming (+5.5) at Utah State (O/U 52.5) | 8 p.m. | CBSSN | Utah State, 28-17 (Wyoming, 44-17) |
| #8 Oklahoma State (-10) at Texas Tech (O/U 55.5) | 8 p.m. | FOX | Oklahoma State, 41-21 (Oklahoma State, 23-0) |
| Louisiana-Monroe (+28.5) at LSU (O/U 57.5) | 9 p.m. | ESPN2 | LSU, 44-17 (LSU, 27-14) |
| New Mexico (+27.5) at Boise State (O/U 48) | 9 p.m. | FS1 | Boise State, 44-14 (Boise State, 37-0) |
| Arizona State (-3) at Oregon State (O/U 59.5) | 10:30 p.m. | ESPN | Oregon State, 31-28 (Oregon State, 24-10) |
| Colorado State (-2.5) at Hawaii (O/U 54.5) | 11 p.m. | PPV | Hawaii, 34-31 (Hawaii, 50-45) |
| Friday, November 19 | |||
| Matchup | Time | TV | Prediction |
| Southern Miss (+15.5) at Louisiana Tech (O/U 48.5) | 8 p.m. | CBSSN | Louisiana Tech, 27-17 (Southern Miss, 35-19) |
| Air Force (-1.5) at Nevada (O/U 53.5) | 9 p.m. | FS1 | Air Force, 27-24 (Air Force, 41-39 3OT) |
| Arizona (+15.5) at Washington State (O/U 52.5) | 9 p.m. | P12N | Washington State, 38-21 (Washington State, 44-18) |
| Memphis (+8.5) at #13 Houston (O/U 60) | 9 p.m. | ESPN2 | Houston, 37-21 (Houston, 31-13) |
| #22 San Diego State (-10.5) at UNLV (O/U 41) | 11:30 p.m. | CBSSN | San Diego State, 28-21 (San Diego State, 28-20) |
| Thursday, November 18 | |||
| Matchup | Time | TV | Prediction |
| Louisville (-19.5) at Duke (O/U 60.5) | 7:30 p.m. | ESPN | Louisville, 44-17 (Louisville, 62-22) |
| Wednesday, November 17 | |||
| Matchup | Time | TV | Prediction |
| Central Michigan (-2.5) at Ball State (O/U 57.5) | 7 p.m. | ESPNU | Central Michigan, 34-28 (Central Michigan, 37-17) |
| Northern Illinois (-1.5) at Buffalo (O/U 59.5) | 7 p.m. | ESPN2 | Northern Illinois, 35-31 (Northern Illinois, 33-27) |
| Tuesday, November 16 | |||
| Matchup | Time | TV | Prediction |
| Toledo (-7.5) at Ohio (O/U 57.5) | 7 p.m. | ESPN+ | Ohio, 31-28 (Toledo, 35-23) |
| Western Michigan (-6) at Eastern Michigan (O/U 66) | 7:30 p.m. | ESPN2 | Eastern Michigan, 38-34 (Eastern Michigan, 22-21) |
| Bowling Green (+17) at Miami (Ohio) (O/U 52.5) | 8 p.m. | ESPNU | Miami, 34-21 (Miami, 34-7) |