Record:
Last week: SU – 7-0; ATS – 4-3-0; O/U – 4-3-0
Overall: SU – 282-79; ATS – 139-147-5; O/U – 135-153-3
(Results in parentheses)
| Friday, October 15 | |||
| Matchup | Time | TV | Prediction |
| #20 Clemson (-13.5) at Syracuse (O/U 45) | 7 p.m. | ESPN | Clemson, 23-20 (Clemson, 17-14) |
| Marshall (-11) at North Texas (O/U 66) | 7 p.m. | CBSSN | Marshall, 37-24 (Marshall, 49-21) |
| San Diego State (-9.5) at San Jose State (O/U 41) | 10:30 p.m. | CBSSN | San Diego State, 31-20 (San Diego State, 19-13 OT) |
| California (-13.5) at #15 Oregon (O/U 54) | 10:30 p.m. | ESPN | Oregon, 31-17 (Oregon, 24-17) |
| Thursday, October 14 | |||
| Matchup | Time | TV | Prediction |
| Navy (+11) at Memphis (O/U 56) | 7:30 p.m. | ESPN | Memphis, 34-24 (Memphis, 35-17) |
| Georgia Southern (+3) at South Alabama (O/U 49.5) | 7:30 p.m. | ESPNU | South Alabama, 30-23 (South Alabama, 41-14) |
| Tuesday, October 12, 2021 | |||
| Matchup | Time | TV | Prediction |
| Appalachian State (-4.5) at Louisiana (O/U 57.5) | 7:30 p.m. | ESPN | Louisiana, 28-24 (Louisiana, 41-13) |
