Record:
This week: SU – 3-1; ATS – 3-1-0; O/U – 1-3-0
Overall: SU – 201-45; ATS – 80-95-3; O/U – 83-91-4
(Results in parentheses)
| Saturday, October 2 | |||
| Matchup | Time | TV | Prediction |
| Pittsburgh (-3) at Georgia Tech (O/U 58) | Noon | ACCN | Georgia Tech, 33-30 |
| Duke (+19.5) at North Carolina (O/U 72.5) | Noon | ESPN2 | North Carolina, 42-28 |
| Memphis (-11) at Temple (O/U 59) | Noon | ESNPU | Memphis, 35-17 |
| Tennessee (+2.5) at Missouri (O/U 65.5) | Noon | SECN | Missouri, 38-30 |
| Charlotte (+10.5) at Illinois (O/U 54) | Noon | BTN | Illinois, 35-24 |
| #16 Michigan (+2) at Wisconsin (O/U 43.5) | Noon | FOX | Michigan, 21-17 |
| Minnesota (+2.5) at Purdue (O/U 46.5) | Noon | BTN | Purdue, 24-20 |
| #10 Arkansas (+16.5) at Georgia (O/U 48.5) | Noon | ESPN | Georgia, 27-17 |
| #13 Texas (-4) at TCU (O/U 65.5) | Noon | ABC | Texas, 38-30 |
| Toledo (-27) at UMass (O/U 56.5) | Noon | FLOF | Toledo, 48-14 |
| Western Michigan (-7) at Buffalo (O/U 59.5) | Noon | CBSSN | Western Michigan, 34-31 |
| Louisville (+7) at Wake Forest (O/U 63) | 12:30 p.m. | CSS | Wake Forest, 38-30 |
| USC (-8.5) at Colorado (O/U 51) | 2 p.m. | P12N | USC, 31-17 |
| Appalachian State (-10) at Georgia State (O/U 54.5) | 2 p.m. | ESPN+ | Appalachian State, 35-17 |
| Eastern Michigan (+1) at Northern Illinois (O/U 60.5) | 2:30 p.m. | ESPN+ | Eastern Michigan, 37-31 |
| #5 Cincinnati (-2) at #3 Notre Dame (O/U 50) | 2:30 p.m. | NBC/Peacock | Notre Dame, 27-24 |
| Louisiana-Monroe (+34) at #15 Coastal Carolina (O/U 57.5) | 2:30 p.m. | EPSN+ | Coastal Carolina, 51-14 |
| Syracuse (+5.5) at Florida State (O/U 51) | 3:30 p.m. | ACCN | Florida State, 24-21 |
| #7 Ohio State (-15) at Rutgers (O/U 58) | 3:30 p.m. | BTN | Ohio State, 34-21 |
| Texas Tech (+7) at West Virginia (O/U 55) | 3:30 p.m. | ESPN2 | West Virginia, 31-20 |
| #4 Oklahoma (-11.5) at Kansas State (O/U 52.5) | 3:30 p.m. | FOX | Oklahoma, 37-27 |
| Ohio (-9.5) at Akron (O/U 55) | 3:30 p.m. | ESPN3 | Ohio, 28-20 |
| Bowling Green (+16.5) at Kent State (O/U 56) | 3:30 p.m. | ESPN+ | Bowling Green, 37-23 |
| Central Michigan (-1) at Miami (Ohio) (O/U 56) | 3:30 p.m. | ESPN+ | Miami (Ohio), 27-24 |
| #6 Oregon (-8) at Stanford (O/U 57.5) | 3:30 p.m. | ABC | Oregon, 38-27 |
| Troy (+6.5) at South Carolina (O/U 43.5) | 3:30 p.m. | SECN | South Carolina, 27-20 |
| #14 Ole Miss (+14.5) at #1 Alabama (O/U 79.5) | 3:30 p.m. | CBS | Alabama, 45-30 |
| Tulane (-3) at East Carolina (O/U 64.5) | 3:30 p.m. | ESPN+ | Tulane, 35-24 |
| UCF (-16.5) at Navy (O/U 53) | 3:30 p.m. | CBSSN | UCF, 41-17 |
| Nevada (+5) at Boise State (O/U 59) | 3:30 p.m. | FS1 | Boise State, 35-28 |
| FIU (+10.5) at FAU (O/U 51.5) | 3:30 p.m. | STAD | FAU, 31-17 |
| USF (+21) at SMU (O/U 68.5) | 4 p.m. | ESPNU | SMU, 47-23 |
| Arkansas State (+2) at Georgia Southern (O/U 66) | 4 p.m. | ESPN+ | Georgia Southern, 31-27 |
| Army (-10) at Ball State (O/U 47.5) | 5 p.m. | ESPN+ | Army, 41-14 |
| Washington State (+7.5) at California (O/U 52) | 5:30 p.m. | P12N | California, 31-17 |
| Louisiana Tech (+18) at #22 N.C. State (O/U 55.5) | 6 p.m. | ESPN+ | TBA |
| #9 Florida (-7.5) at Kentucky (O/U 56) | 6 p.m. | ESPN | TBA |
| UNLV (+21) at UTSA (O/U 56) | 6 p.m. | ESPN+ | TBA |
| Southern Miss (+1.5) at Rice (O/U 44.5) | 6:30 p.m. | ESPN3 | TBA |
| Air Force (-11.5) at New Mexico (O/U 46) | 6:30 p.m. | FS2 | TBA |
| Kansas (+34.5) at Iowa State (O/U 57) | 7 p.m. | FS1 | TBA |
| #19 Baylor (+3.5) at #21 Oklahoma State (O/U 47) | 7 p.m. | ESPN2 | TBA |
| Mississippi State (+7) at #12 Texas A&M (O/U 46) | 7 p.m. | SECN | TBA |
| Marshall (-10.5) at Middle Tennessee (O/U 66) | 7 p.m. | STAD | TBA |
| Liberty (+2.5) at UAB (O/U 49) | 7 p.m. | CBSSN | TBA |
| Boston College (+14.5) at #24 Clemson (O/U 46) | 7:30 p.m. | ACCN | TBA |
| Northwestern (+11.5) at Nebraska (O/U 51.5) | 7:30 p.m. | BTN | TBA |
| Western Kentucky (+10.5) at #23 Michigan State (O/U 66) | 7:30 p.m. | BTN | TBA |
| Indiana (+12.5) at #11 Penn State (O/U 53.5) | 7:30 p.m. | ABC | TBA |
| UConn (+15) at Vanderbilt (O/U 51) | 7:30 p.m. | ESPNU | TBA |
| Louisiana (-12.5) at South Alabama (O/U 53) | 8 p.m. | ESPN+ | TBA |
| Washington (+1.5) at Oregon State (O/U 57.5) | 9 p.m. | P12N | TBA |
| #18 Auburn (+3) at #20 LSU (O/U 56) | 9 p.m. | ESPN | TBA |
| Old Dominion (+5.5) at UTEP (O/U 48.5) | 9 p.m. | ESPN+ | TBA |
| New Mexico State (+26) at San Jose State (O/U 53) | 10:30 p.m. | Local | TBA |
| Arizona State (+3) at UCLA (O/U 56) | 10:30 p.m. | FS1 | TBA |
| #25 Fresno State (-11) at Hawaii (O/U 64.5) | 11 p.m. | CBSSN | TBA |
| Friday, October 1 | |||
| Matchup | Time | TV | Prediction |
| Houston (+4.5) at Tulsa (54.5) | 7:30 p.m. | ESPN | Houston, 30-23 (Houston, 45-10) |
| #8 Iowa (-3.5) at Maryland (47.5) | 8 p.m. | FS1 | Iowa, 30-17 (Iowa, 51-14) |
| #17 BYU (-9) at Utah State (O/U 61.5) | 9 p.m. | CBSSN | BYU, 38-27 (BYU, 34-20) |
| Thursday, September 30 | |||
| Matchup | Time | TV | Prediction |
| Virginia (+5) at Miami (Fla.) (O/U 62) | 7:30 p.m. | ESPN | Miami, 34-27 (Virginia, 30-28) |
